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Both resistance mechanisms are based on single point mutations and, as the patient had no known contacts with individuals of Asian or Pacific origin, it is, therefore, most likely that these SNPs were derived de novo <a href=https://sildenafil.buzz>wht does viagra do</a> Women classified as PMs had i two dysfunctional alleles for example, CYP2D6 3 3, 3 4 or 4 4, or ii one dysfunctional allele CYP2D6 3 wt, 4 wt, 5 wt or 6 wt with concurrent use of a moderate CYP2D6 inhibitor or iii a functional genotype wt wt with co administration of a strong CYP2D6 inhibitor Goetz et al, 2007
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